Altered immune function in demyelinative disease

Nanosized aluminum altered immune function.

On the basis of their uses in jet fuels and munitions, the most likely scenario for aluminum nanoparticle (NP) exposure is inhalation. NPs have been shown to be capable of penetrating deep into the alveolar regions of the lung, and therefore human alveolar macrophages (U937) with human type II pneumocytes (A549) were cultured together and exposed to NPs dispersed in an artificial lung surfactan...

Altered Immune Function during Long-Term

Altered immune function in alloxan-induced diabetes in mice.

Macrophage lectin receptors that recognize bacterial cell wall sugars are reduced in alloxan diabetic mice. This is in contrast to the expression of macrophage Fc (IgG2b) receptors which remains unaltered. Peritoneal macrophages, from diabetic and normal mice, were used as a source of accessory cells in an antigen dependent T cell proliferation assay with unopsonized Staph. epidermidis as the a...

Altered proteasomal function in sporadic Parkinson's disease.

Parkinson's disease (PD) is characterized pathologically by preferential degeneration of the dopaminergic neurons in the substantia nigra pars compacta (SNc). Nigral cell death is accompanied by the accumulation of a wide range of poorly degraded proteins and the formation of proteinaceous inclusions (Lewy bodies) in dopaminergic neurons. Mutations in the genes encoding alpha-synuclein and two ...

Disease associations and altered immune function in CD45 138G variant carriers.

The CD45 antigen is a haemopoietic cell specific tyrosine phosphatase essential for antigen receptor mediated signalling in lymphocytes. Expression of different patterns of alternatively spliced CD45 isoforms is associated with distinct functions. We recently identified a polymorphism in exon 6 (A138G) of the gene encoding CD45 (PTPRC) that results in altered CD45 splicing. The 138G allele is p...